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L-Arginine Amino Acid LJ100™ (Eurycoma Longifolia) Horny Goat Weed (Epimedium) Bioperine® Extract Increase Nitric Oxide (NO)

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LJ100 (Tongkat Ali), Eurycoma Longifolia

This additionally stems the aging process, improves energy, alertness and sexual function, and helps to reduce risk factors associated with aging. Additionally, rigorous toxicology trials have shown LJ100™ to be safe even at 3000 times greater than the suggested dosage. Now men can enjoy the secret of Malaysian men over 40 years old who traditionally consume Eurycoma root tea as a daily tonic. Now nature can play an important role in assisting men to fight the undesirable physiological challenges of aging and enjoy a more youthful function!

Overview of LJ100, Eurycoma Longifolio Extract

LJ100™ is a standardized Eurycoma Longifolia extract, containing 22% Eurypeptides, a bioactive glyco protein that is now clinically proven for its androgenic properties. The plant is also commonly known as Tongkat Ali (Ali’s walking stick) and is commonly found along the hilly jungle slopes of Malaysia. The name Ali is associated with a male warrior who was well known for his prowess. Besides its aphrodisiac properties, Eurycoma has been used as traditional remedies for fever, ulcer, malaria, reducing high blood pressure and fatigue.

LJ100™ has undergone a patented BAT extraction process to capture 22% biologically active Eurypeptides™, proven in research to be responsible for increasing libido, improving sports performance, increasing fertility, and activating the enzymes that metabolize the various androgens. Created by the original researchers at the Forest Research Institute of Malaysia (FRIM) and University of Malaya, LJ100™ (22% Bioactive Eurypeptides) has shown - in human clinical trials - an ability to increase DHEA and free testosterone, decrease Sex Hormone Binding Globulin (SHBG), improve HDL, modulate cortisol, and increase IGF-1 level.

LJ100 Clinical Research for Use in Roaring Tiger Products

WATER - SOLUBLE EXTRACT OF LJ100TM AS A POTENTIAL NATURAL ENERGIZER FOR HEALTHY AGING
MENM/.M TAMBI, S. OTHMAN AND J.M. SAAD Testosterone levels drop by about 10 percent every decade starting at age 30. At the same time, Sex Hormone Binding Globulin (SHBG) is increasing. SHBG traps much of the testosterone that is still circulating and makes it unavailable to exert its effects in the body's tissues. Low bioavailable testosterone levels may cause low sex drive, decreased muscle mass and strength, increased body fat, osteoporosis, and increased cardiovascular risk.

In 2003, Dr. Ismail Tambi and Dr. Johari Saad conducted a pilot human clinical trial at the Specialist Reproductive Research Center, National Population & Family Development Board, Malaysia. In this study 23 volunteers took 100mg of LJ100™ for three weeks. The Sexual Health Inventory Questionnaire (SHIQ) results showed 62% of volunteers having an increased or maximum score, showing increase in sexual desire and success in the attempts at sexual intercourse. Aging Male Score (AMS) were lowered demonstrating 91% improvement of sexual score, 73% improvement in the physical score, 91% improvement of the psychological score, and 52% improvement in vasomotor score.

Total testosterone levels were not significantly different suggesting that LJ100™ does not have any effect on steroidogensis. Analysis of DHEA showed gradual increase from 26% after 1 week to 47% after 3 weeks. This suggests that LJ100™ may influence the DHEA production, which would in turn be aromatized to testosterone. SHBG levels were reduced in 36% of the volunteers after one week and 66% after 3 weeks. This suggests that the extract could have an effect on the production of SHBG. Consequently, when SHBG level declines, the Free Testosterone Index (FTI) goes up. FTI showed an escalation of 39% of subjects after 1 week and 73% after 3 weeks. This study showed that LJ100™ can provide sufficient free testosterone for the body and can be a valuable health elixir for the aging men.

SHIQ results showed 62% of the cases having an increased or maximum score. Breakdown of the results showed increase in sexual desire and success in the attempts at sexual intercourse while on treatment and related well with the PAD AM score's results showing improvement in sexual attempts and desire. PADAM score demonstrated that 82% of the cases showed a decrease in total score. The breakdown included: 91% improvement of sexual component, 73% improvement in the physical component, and 82% improvement of the psychological component. The Vasomotor score showed improvement in 52% of the subjects. Analysis of DHEA showed gradual increase in the level from 26% after 1 week to 47% after 3 weeks. This suggests that the extract may influence the DHEA production, which would in turn subsequently be aromatized to testosterone. SHBG analysis showed that levels were reduced in 36% of the cases after one week. The reduction went up to 66% after 3 weeks. This suggests that the extract could have an effect on the production of SHBG. Consequently, when SHBG level declines, the Free Testosterone Index (FTI) goes up. FTI analysis showed an escalation of 39% of subjects after 1 week and 73% after 3 weeks. THE ANABOLIC EFFECTS OF LJ100 TM Sareena Hanim Hamzah & Ashril Yusof In a double blind, placebo controlled study conducted by Dr. Sareena from the Department of Sport Science at the University of Malaya in 2000, 14 healthy adult males received either 100 mg/day of LJ100™ (22% Bioactive Eurypeptides) or placebo for 8 weeks. Both groups performed an intensive strength training program for 8 weeks. Although the testosterone level was not measured during the test period, an increase in fat free mass in LJ100™ group may be linked to the rise in steroidal hormones in the body. LJ100™ group showed greater decreased fat mass compared to the placebo; this could be explained by the higher metabolic rate after consuming LJ100™.

In this study, we observed a greater increment in muscle strength test for the LJ100™ group which related to a lower muscular neural firing rate, which we suggest was due to further increased testosterone levels. An increase in arm circumference observed in the treatment group could be explained by the testosterone enhancing effect of LJ100™. In conclusion, results obtained from this pilot study suggest that the administration of LJ100™ (22% Bioactive Eurypeptides) increased fat free mass, reduced fat mass, increased muscle strength and size. During and after the administration of LJ100™ there were no adverse effects noted within the LJ100™ group.

	Placebo (100 mg/d)		LJ100 (100 mg/d)
Parameters	Pre (mean ± SD)	Post (mean ± SD)	Pre (mean ± SD)	Post (mean ± SD)
FFM (kg)	52.44± 3.77	52.77± 7.18	52.26 ± 7.18	54.39 ± 7.43
Fat Mass (%)	22.83 ± 2.43	21.33 ± 2.35	31.30 ± 5.48	28.44 ± 6.43
1 RM	77.29 ± 8.90	79.43 ± 8.83	73.71 ± 8.90	78.71 ±17.00
Arm Circ (cm)	29.8 ± 3.70	30.7 ± 3.86	30.87 ± 1.88	32.67 ± 1.96
sEMG (mV)	127.95 ± 30.90	98.8 ± 50.10	121.77 ± 40.0	90.47 ± 64.60

Fat free mass of the group supplemented with LJ100 Eurycoma water soluble extract showed a significant increment of approximately 2.1 kg. There were no significant changes in fat free mass in placebo. Body fat percentage were significantly decreased in treatment and placebo. However, a greater decrement was shown in treatment compared to placebo i.e. 9.14% and 6.57% respectively. The 1 RM test muscle strength test showed an increase in gross muscle power in both groups. The treatment group showed a greater increment in strength compared to placebo i.e. 6.78% and 2.77% respectively. The mean arm circumference in treatment group increased significantly by 1.8 cm following the supplementation while no significant changes observed in placebo group. The mean sEMG reading of the treatment and placebo showed a significant decrement in values after going through the exercise program. However, the treatment group showed 2.92% higher reduction in electrical activity of the muscle measured at the end of the experiment period compared to placebo (25.70% and 22.78% respectively). During and after the administration of Eurycoma, no adverse effects were noted within the treatment group. LJ100 Saliva Testosterone Test
Sareena Hanim Hamzah & Ashril Yusof Nine volunteers ages 26-52 were given 200mg of LJ100™ for 10 days. Volunteers 1-5 who engaged in physical exercise experienced a 70% to 133% increase in Free Testosterone. Volunteers 6-9 who did not exercise experienced a 35% to 70% increase in Free Testosterone level. This study shows that exercise will enhance the effects of LJ100™ as it modulates testosterone level according to the body’s needs.

		Pre-Treatment		Post-Treatment		Results
Volunteer	Age	ng/dl	blood	ng/dl	blood	% Increase
1	26	860	30	1,650	50	91.86%
2	28	580	30	985	35	69.83%
3	35	875	40	1,576	60	6080.11%
4	24	950	45	2,210	55	132.63%
5	29	755	30	1,345	35	78.15%
6	48	650	20	875	30	34.62%
7	52	450	25	765	35	70.00%
8	50	585	25	875	35	49.57%
9	42	350	30	480	35	37.14%

• Volunteers 1-5 are athletes - data are an average of 3 different studies at different times
• Volunteers 6-9 do not exercise on a regular basis
• Dosage 2x2 (50mg/capsules) morning & evening for 10 days
• Normal range for athlete 800 = 150ng/dl of blood

Data - preliminary data - more work to be carried out

The Effects of LJ100TM on Fertility & Sexual Behavior in Mice

Between 1993 and 1994, Dr. Johari Saad, head of the Biochemistry Department at University of Malaya conducted multiple mice studies to evaluate the fertility and aphrodisiac effects of LJ100™. 48 mice were divided into 3 sets of 4 groups. Group 1 was treated with saline; Group 2 female was treated with LJ100™ and male with saline; Group 3 both male and female treated with LJ100™; Group 4 male treated with LJ100™ and female with saline. In this study, we observed that the treated males were very aggressive sexually and showed a higher frequency of mounting compared to the control group.

Group	30 min	60 min	Litter Size	Male:Female
1	5	4	7	1:1
2	2	0	4	1:1
3	6	5	10	3:1
4	15	10	16	3:1

Group 3 and 4, where male mice were treated with LJ100™, yielded a litter size up to 76% larger than the control group. The increase was due to increased sperm concentration (125% increase), motility (38% increase), and velocity which increased fertilization rates (82.7% vs. 94.8%). Group 3 and 4 also showed a 3:1 male to female offspring ratio. LJ100™ may have a selective action towards the Y sperm during spermatogenesis or prefer to enhance the development and fertilization of Y sperm. Dr. Johari also observed 60% increased energy production through glycolysis and oxidative phosphorylation, 80% increased ATP production observed in liver homogenates, 60% increased Cyclic GMP and Cyclic AMP in penile tissues.

Aphrodisiac Properties of LJ100™(22% Bioactive Eurypeptides)

Sexual stimulus in males leads to a release of nitric oxide (NO) into the blood vessels of the corpus cavernosa (erectile tissue). NO activates enzyme guanilate cyclase activity which increases cGMP (cyclic guanosine monophosphate ) concentration, which allows for the relaxation of penile arteries, leading to increased blood flow and penile erection. In the absence of NO release, cGMP is terminated by enzyme PDE5.  cAMP also affects penile erection.  cAMP (cyclic adenosine monophosphate) is modulated by  adenyl cyclase, which result in a decline in the free calcium concentrations, which allows for the relaxation of penile smooth muscle leading to vasodilatation and erection.

In 2002, Dr. Azimahtol, Faculty of Science & Technology from the University Kebangsaan Malaysia conducted a study to evaluate the effect of LJ100™ (22% Bioactive Eurypeptides) was compared with the effectiveness of sildenafil citrate (Viagra) in triggering penile erection. Sildenafil citrate is a potent PDE5 inhibitor. By blocking the action of PDE5, the NO-induced increase of cGMP concentration is augmented and prolonged.

Rabbit corpus cavernosum tissues were treated with LJ100™ (22% Bioactive Eurypeptides) and sildenafil citrate at different concentrations (0, 1.25, 1.875, 2.5, 3.125 and 3.75 µg/ml) and incubation time; cGMP and cAMP levels were measured. LJ100™ increased the level of cGMP in rabbit corpus cavernosum to almost 4-fold at 3.125 µg/ml concentration. Sildenafil citrate increases cGMP in rabbit corpus cavernosum to 5-fold at 10-4M concentration. LJ100™ was found to increase cAMP levels in corpus cavernosum, even in the absence of sexual stimulus, and there were no significant increases of cAMP levels in the corpus cavernosum tissue treated with Viagra. Results of this study validate the aphrodisiac properties of LJ100™ which increases and enhances the levels of cGMP and cAMP, which ultimately leads to penile erection.

Androgen Biosynthesis of LJ100™

Testosterone, or male sex hormone, plays a key role in developing and maintaining masculine sexual organ, and promotes secondary sexual characteristics, including the appearance of facial hair, sexual desire, and sexual behavior.   Testosterone also stimulates metabolism, which promote fat burning, increases the formation of red blood cell, and accelerates muscle growth. Testosterone is synthesized by an enzymatic sequence of steps, breaking down cholesterol, via activation of CYP17 (17 a-hyroxylase/17,20 lyase) enzyme to pregnenolone.  CYP 17 is involves in the early stage of steroid biosynthesis.  Pregnenolone is the ultimate parent steroid compound.  Pregnenolone is a steroid precursor, manufactured from cholesterol in the body.  Pregnenolone is a precursor to cortisol, DHEA, Progesterone, and Testosterone.

Between 2002 and 2003, a study was conducted by Dr. Harniza and Dr. Johari from the University of Malaya to isolate the bioactive Eurypeptides and test the biosynthesis of various androgens. The in vitro results from this study showed that Eurypeptides significantly increased CYP17 enzymes compared to the positive control, suggesting that more of the CYP17 enzyme is being produced to metabolize pregnenolone to yield more testosterone and progesterone. We have also seen 180% increase in testosterone and 190% increase in progesterone.

ug steroid/10 mg protein
Steroid Extract	Blank	Control	LJ100 (2)	LJ100 (3)
an-a	22.57	32.7	109.99	207.26
testosterone 180% increase	0.98	1.68	2.43	2.37
7-OH preg	2.43	5.15	1.41	1.31
progesterone 190% increase	3.36	6.39	12.30	13.20

Low amounts of pregnenolone and 17-OH pregnenolone compared to control also confirm that more CYP17 is activated to convert pregnenolone and 17-OH pregnenolone into progesterone and testosterone. Pregnenolone is also a precursor for the synthesis of pheromones. The study showed that Eurypeptides influence the synthesis of pheromones by significantly increasing An a--a pheromone that plays an important role in communication, psychological and sexual behavior in humans, confirming the aphrodisiac aspects of LJ100™.

Human Toxicology and Clinical Study:

In 2004, Dr. Ismail Tambi conducted a double-blind placebo controlled human clinical trial at the Specialist Reproductive Research Center, National Population & Family Development Board, Malaysia.  20 male volunteers of various health conditions from the ages of 38 to 58 were randomly given either 200, 400, or 600 mg of LJ100™ (22% Bioactive Eurypeptides) or placebo for 2 months. The SHIM (Sexual Health Inventory for Male) scores were elevated to upper normal level showing improvement in sexual desire and performance for a majority of the volunteers. The Aging Male Score (AMS) were lowered showing improvement in sexual, physical, psychology, and vasomotor domain for majority of the volunteers. Testosterone and DHEAS levels showed high normal levels when compared to baseline and is consistent with the excellent QOL (Quality of Life) score. LJ100™ modulates the production of DHEAS, which would in turn be aromatized to testosterone. Bioavailable testosterone is needed to maintain wellness and enhance libido.

Full blood examinations showed normal limits even at the 600mg dosage for all tests. LJ100™ does not interfere with the platelets or hemoglobin and does not have any toxicity to the RBC. The liver function test showed no liver toxicity even at high doses of LJ100™. Renal function test showed that LJ100™ has no harmful effect on the renal system even for men whose renal function is affected (as seen in diabetics). Some volunteers even showed improved or normal levels of uric acid at the end of the trials. Tumor markers are sensitive indicators of cellular stress. AFP (Alpha Fetal Protein) identifies testicular cancer; PSA (Prostate Specific Antigen) is used to detect prostate cancer. All tumor markers were within normal levels even at 600mg dosage of LJ100™. The lipid studies showed increment of high-density lipoprotein (HDL Cholesterol –good cholesterol) levels. Elevations of HDL are normally associated with a lower risk of heart attack. Diabetic volunteers showed an improved level of blood glucose levels. LJ100™ does not exert hypoglycemic effects but may have an influence on the cellular uptake of glucose.

The cortisol levels were in the higher than normal level for the LJ100™ group as opposed to the placebo group. The positive benefits of high cortisol are enhancement of immune response during illness and body defense during health crisis. The negative aspect of cortisol is associated with the metabolic syndrome X, which includes obsesity, type-2 diabetes, hypertension, and increased cardiovascular risk. This study suggests that LJ100™ has influence over the adrenal gland and modulates the release of cortisol.

Low thyroxin indicates low BMR (Basal Body Metabolism Rate). The majority of volunteers on LJ100™ have higher than normal levels of thyroxine compared to the placebo group, meaning higher metabolism rate which can be translated to weight management.

IGF-1 regulates cellular growth and development. Premature reduction in IGF-1 causes cell death. IGF-1 is the anti-aging hormone as it increases muscle bulk and lean body mass and cell regeneration. Volunteers taking the LJ100™ had higher than normal levels of IGF-1 at the end of the trials. Some with a low IGF-1 level increased to a normal level after 1 week. The placebo group showed no change in IGF-1 levels. This study suggests that LJ100™ has a secretagogue effect on growth hormone and modulates the release of IGF-1; in turn, making it a great anti-aging supplement.